Gastroretentive Orlistat Microspheres: Formulation, Characterization, and In Vitro Evaluation
نویسندگان
چکیده
منابع مشابه
Gastroretentive Orlistat Microspheres: Formulation, Characterization, and In Vitro Evaluation
The present study involves the preparation and evaluation of floating microspheres of orlistat for improving drug bioavailability by prolongation of gastric residence time. The microspheres were prepared by a solvent diffusion–evaporation technique using inert polymers (Eudragit RL100, cellulose acetate, and ethyl cellulose). The effect of three formulation variables (i.e., drug/polymer ratio [...
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The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...
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The present study involves preparation and evaluation of floating microspheres with cimetidine as model drug for prolongation of gastric residence time. The microspheres were prepared by the solvent evaporation method using polymers hydroxypropylmethyl cellulose and ethyl cellulose. The shape and surface morphology of prepared microspheres were characterized by optical and scanning electron mic...
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Objective: The objective of this study was to formulate and evaluate sustained release gastro retentive microspheres of furosemide using mucoadhesive polymers. It was expected that gastro retention plus mucoadhesion would contribute to extending the rate of drug release in the acidic medium in vitro, thereby projecting this formulation as a potential candidate for improvement of oral bioavailab...
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BACKGROUND AND THE PURPOSE OF THE STUDY The objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation. METHODS Microballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2011
ISSN: 1521-298X
DOI: 10.14227/dt180311p72